ITunes will not open on first try

For the past several versions, when I try to launch iTunes for the first time after starting/restarting my computer, it simply will not open. The icon will jump up and down in the dock for a while before settling down and saying "Application is not reponding". I have to force quit it and reopen. After I force quit the first time, it opens just fine until I restart my computer again. Not a big issue, but it IS a little annoying. Any thoughts on how to fix this?
Here's what I'm currently running:
13" MacBook Pro - 2.66GHz Core 2 Duo
OSX 10.6.8
iTunes 10.5.2 (11)
I run a couple apps on start up, but nothing crazy. I haven't tried disabling those, then opening iTunes, but I can't imagine it's one of these (although stranger things have happened I'm sure.) I run Caffine, Quicksilver, SugarSync File Manager, and Day-O on start up.
Any thoughts or suggestions?
RickydB

How long after starting the computer do you start iTunes? I see you're running a number of system hacks and I wonder if they are taking some time loading and somehow interfering. You could try disabling some and see if it changes iTunes behavior, then decide on your priorities.
A quick way to test would be to hold down the shift key while starting the computer so it boots to Safe Mode.
What is Safe Boot, Safe Mode? (Mac OS X) - http://support.apple.com/kb/HT1564
Safe Boot takes longer than normal startup - http://docs.info.apple.com/article.html?artnum=107394
Safe boot mode runs a directory check command similar to that used by Disk Utility's repair. In Tiger it ignores some stored information (cache) that is normally read that speeds up the boot process, and it moves some caches to the trash. It also uses only System fonts and disables all Startup Items, third party items, and any Login Items. Networking and some video components may also be disabled.
Message was edited by: Limnos

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ITunes will not open on first try

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