ITunes won't open after I close it

Whenever I am done with iTunes for a while, I usually close it.
Recently, when I close iTunes, it seems to stay open in the process list of task manager and will not go away - period.
I have tried "end process", and also tried the taskkill command from command prompt to no avail.
This means that when I go to open iTunes later, I can't.
Can someone please address my problem and help me out?
Thanks very much,
Ash

Assuming you have a variation of iTunes freezes on closing, try the following:
If you are using NOD32 see this article:
http://www.eset.com/support/kb.php?option=com_kb&Itemid=29&page=articles&article id=760
Freeze on closing has also been associated with the bonjour service.
This article tells you about the Bonjour service and how to turn it off as a test:
http://support.apple.com/kb/HT2250?viewlocale=en_US
If you don't need Bonjour and it is causing the problem, you can uninstall it and iTunes will still work except for the features requiring Bonjour.
If that doesn’t work some people have found that uninstalling Apple Mobile Device support works. iTunes works OK without it, but it is required for the iPhone or Touch.

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