ITunes won't open and reinstalling doesn't help

Each time I try to open iTunes, I get the following error:
"The folder 'iTunes' cannot be found or created, and is required. The default location for this folder is in the 'My Music' folder."
I have tried uninstalling iTunes and reinstalling it, but I always get the same message when I try to open it. I had been using it without any problems for the past year, but last month this issue began and I'm not sure why.
Also, I keep my music files on my external drive, but iTunes is installed on my computer. Not sure if this has anything to do with it.

Try rebuilding the library:
http://docs.info.apple.com/article.html?artnum=93313

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