Itunes won't open on my computer how do I open it

trying to back up my iphone4s and itunes not automatically opening, nor is it opening when I right click on it and try to open it, It was working fine this AM when I downloaded some pictures off my phone. How do i resolve this problem?

Every time I go to open it a message pops up saying that it can't be run.
What's the precise text of the message, please? (There's a few different ones I can think of that you might be getting.)

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