Itunes wont open, I get "itunes application could not be opened. An unknown error occurred (-50)"

I'm on Windows 7 - using itunes daily without problems and suddenly itunes wont open, I get "itunes application could not be opened. An unknown error occurred (-50)"  The only thing I can think is I think there was a download in progress when I shut down the computer.
I tried uninstalling and reinstalled, but I get the same thing. I tried clearing the itunes folder and reinstalling, same thing. help!

Doublechecking. When you did the complete uninstall, were you using the following document as a guide?
Removing and reinstalling iTunes, QuickTime, and other software components for Windows Vista or Windows 7
(If damaged program files are involved here, a standard install might not remove them, and a reinstall might not then replace them. So the Verify iTunes and related components are completely uninstalled section is an important step.)

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