Ituneshelper.dll could not load in 64-bit mode

Question

I am receiving this message when opening iTunes after the update and neither my ipod nor ipad will connect and be recognized.

Answer 1

For general advice see Troubleshooting issues with iTunes for Windows updates.
The steps in the second box are a guide to removing everything related to iTunes and then rebuilding it which is often a good starting point unless the symptoms indicate a more specific approach. Review the other boxes and the list of support documents further down the page in case one of them applies.
Your library should be unaffected by these steps but there is backup and recovery advice elsewhere in the user tip.
If the advice above doesn't resolve things you could try this alternate version:
iTunes 12.1.0.71 for Windows (64-bit - for older video cards) - itunes64setup.exe (2015-01-28)
which is a 64-bit installer for the 32-bit version of the core application, similar to previous 64-bit releases.
Or roll back to the previous build:
iTunes 12.0.1.26 for Windows (32-bit) - iTunesSetup.exe (2014-10-16)
iTunes 12.0.1.26 for Windows (64-bit) - iTunes64Setup.exe (2014-10-16)
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