Jumpy, Glitchy Mouse and No Audio

I left on vacation for a week, leaving behind a smoothly running iMac i7. I put the computer to sleep while I was gone.
Upon returning home, the computer is running horribly. I installed updates, and it seems to be running painfully slow. Even as I type now it struggles to keep up to my typing speed. The mouse is glitchy and jumpy and certainly not smooth. The volume control on my menu bar is greyed out and my keyboard volume controls do not work.
I am running 10.6.3 on a 27" iMac with a 2.8 GHz Intel Core i7. I'm not using the mighty mouse, just a basic USB mouse.
Suggestions?
< Edited by Host >

Hi, why not go the SMC route?
then Repair Permissions & ReBoot......L

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