Keep gettinng invalid E drive when trying to install itunes. Help

Cant upgrade my software on my iPhone 4 due to not being able to download and install the latest itunes...  Please help!!!

Open a Windows Command prompt, e.g. Hit Start > Run, type in CMD and press OK.
Type in SUBST E: C:\ and press enter/return.
This will map E: to C: until the machine is restarted or you enter SUBST E: /D at the command prompt. Now you can try uninstalling or upgrading the software again. (If upgrading the software, install the software in the default location, not on the E:\ drive.)
tt2

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