Kernel Panic on opening Mail application

Question

When I try to open the Mail application I get this message
The mailbox “~/Library/Mail/Mailboxes/Outbox.mbox” is currently locked by “(null)” on host “<?xml version="1.0" encoding="UTF-8"?>”. If you open a mailbox that already is in use, you may damage its contents.
And it give me three options
1) Open read only 2) Quit 3) Open Anyway
When I click on either "Open read only" or "Open Anyway" I get a Kernel Panic and I have to restart the computer.
Any help will be appreciated

Answer 1

Appears that you have some file system corruption. DiskWarrior by Alsoft will probably fix the problem.
http://www.alsoft.com/DiskWarrior/index.html
However, most kernal panics are related to hardware problems. Can you isolate to a hardware device?
Issues with a hardware device can sometimes appear to be software issues, but are not resolved with software troubleshooting. Eliminate hardware as a cause (or conversely, isolate the issue to software):
1. Disconnect external devices. If the computer is an iBook or PowerBook computer, disconnect all external devices. For an iMac, disconnect all devices other than the Apple keyboard and mouse. For a Power Mac, disconnect all external devices other than one display (which should be connected to an original, built-in video port), and the original Apple keyboard and mouse. If this resolves the issue, add devices back one at a time (shut down first if the device requires it) to further isolate the issue.
2. Insert the Apple Hardware Test CD that came with your computer (if one did). Use the extended test. If any issues are found proceed to step 3, or contact AppleCare or your nearest Apple Authorized Service Provider to arrange for diagnostics and service as necessary.
3. Shut down the computer and remove any third-party memory upgrades, expansion cards, additional hard drives, or other internal hardware upgrades. If you are not comfortable doing this, an Apple Authorized Service provider can assist. A service fee may be charged if the issue is not related to your Apple hardware. Alternatively, you may wish to skip this step and go to "Reinstall Mac OS X" below.
* If the issue is resolved, add your devices back one at a time. When the issue returns, remove the most recently-added device. If the issue goes away again, you have identified the cause. If software was included with the device, try deleting and reinstalling it. You may also wish to contact the vendor or manufacturer of that device for specific troubleshooting steps.
* You may want to test devices on all available ports into which they can be used. If a USB device works on USB port 1 but not on USB port 2, try connecting other devices to port 2. It is possible that your computer's ports aren't working properly.
Look at these links.
What's a "kernel panic"? (Mac OS X)
http://docs.info.apple.com/article.html?artnum=106227
Mac OS X Kernel Panic FAQ
http://www.macmaps.com/kernelpanic.html
Mac OS X Kernel Panic FAQ
http://www.index-site.com/kernelpanic.html
Resolving Kernel Panics
http://www.thexlab.com/faqs/kernelpanics.html
Cheers, Tom