Left mouse click does not work

I have a mid-2010 Mac Book Pro 15", 8GB, Samsung 840 500GB SSD, w/ Mountain Lion.
About four to six months ago I started having issues where the left mouse button would stop working when I left the computer on unattended (but not asleep) for extended periods of time.
I have both a bluetooth keyboard and magic mouse connected most of the time, but when the issue occurs the button issue extends to both the external mouse and the on-system touch pad.
The issue started at about the same time that I took my system in to be repaired after the harddisk started failing. The system has since had the OS reloaded (twice) and the replacement harddisk has since been replaced with and SSD, so I if the original service is to blame, it is a peripheral issue (damage, firmware update, etc).
Here is where it gets really crazy... rebooting does NOT fix the issue. Shutting down and restarting does NOT fix the issue. Hard power off (holding the power until it hard-off's the system) then restarting DOES fix the issue.
The problem is reproducible, and since I've now demoted this laptop to being my television PC, it gets left on idle all the time (and hense the problem occurs all the time).
To the best of my knowledge I have all the latest patches and firmware loaded.
I suspect this is a low level firmware/hardware bug, but have no way to confirm and have had no luck with finding answers here or via the store.
Any assistance is appreciated!!

I can left mouse click any other program successfully. I can only left mouse click Firefox one time and then it refuses to work. I set the default mouse structure and pressed apply. It does me no good. There must be another cause for no other program has problems except for Firefox.

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Left mouse click does not work

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