Letters disappear when reducing file size of PDF.

I have a multi-page PDF file that contains bitmap images and vector text. It was originally created in InDesign and exported to PDF. When I exported the PDF at 300 dpi, everything rendered beautifully. However, when I reduced  the image quality through the PDF optimizer (set all images to 80 dpi at high quality), random letters disappered from my text. Weird, since these are vectors and should not be affected by lowered dpi settings anyway.
The gaps are there where the letters should be, and I can even use my text cursor to copy and paste those missing letters into a text file, for example. So basically, all the data is still there, the letters just aren't showing up. This is not resolved by zooming in, and most unfortunately, the letters also do not show up when the document is printed. I have all my fonts embedded. Could this be due to the fact that I am using a lightweight font? (Verlag Extra Light). The letters that go missing seem to be completely at random. I have Acrobat Professional 8.

Thanks for your suggestions. Yes, they all say embedded subset. I will try to replace the fonts just to see what happens, though Verlag is pretty central to the design of this project. I can't see it being a quality issue since it's a high-end font from Hoefler & Frere Jones (not to mention specially purchased for the project!)
I will note that I was able to make some progress by using the Advanced Editing -> Touch Up Text tool to manually retype the missing letters. I did get them to show up that way. Unfortunately this is very time consuming and tends to mess up the text formatting. Still curious what causes this.

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