Lightroom "gamma spikes?" What's going on and how do I fix it?

I have used LR since its inception and don't recall that I have ever had this issue until recently.
While editing still images in Lightroom, I keep getting these odd shifts in the images that make them momentarily mega washed out, almost like a spike in gamma. It usually occurs when I use quick adjust on an image (or a few), but sometimes it just does it on its own. Closing the LR window and immediately reopening it solves the issue, but only for that instance. Otherwise, I have to wait a moment for it to fade back to normal.
I can't tell, but it doesn't seem to effect the rest of my monitor, only the images in LR.
What could this be and how could I fix it?
(I am on a 2012 Mac Pro 12-Core with 28GB RAM)
Thanks in advance for any responses.

That may be avoiding the problem. See apple's article on what safe boot does.
You may want to run these "standard" fixes if the problem persists.
Check the amount of free space on your harddrive. You should have a several gigs free.
You should run disk utility
a) verify the disk
b) update your permissions.
Try a safe boot.
Shutdown your machine. Hold down the shift key. Poweron. Wait awhile Wait awhile while you harddrive is being checked.
http://support.apple.com/kb/ht1455
You may want to run applejack to clean up your machine.
http://applejack.sourceforge.net/

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