Lightroom won't start-Help

I am running Lightroom 2.5 on a Windows Vista System. I have been using Lightroom since version 1.0. My Lightroom has suddenly quit working, When I start I either get a message that Lightroom has stopped working and must be shut down or it dims and says not responding. I have left it in not responding mode for 5 hours with no luck. I have tried loading other catalogs and even creating a new catalog and I get the same results. What I see when it goes to Not Responding is strange. Customizations that I have made are not shown. The folders listed do not seem to be the folders that should be shown for the catalog and I sometimes get a screen asking me to set program update options. What has happened and what can I do? Help

I have tried creating a new catalog. Same result.
The message I get says: Adobe Photoshop Lightroom 64-bit has stopped working
                                     A problem caused the program to stop working correctly.
                                     Windows will close the program and notify you if a solution is available.
Everything else seems to be working normally.

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