Ligthroom sometimes starts and sometimes not...

I have a mac with 10.5.8, ligthroom sometimes starts and sometimes not, "the program is not responding" and do not get to start. I'd like to resolve this error, which apparently does not have a defined behavior pattern. Thank you.

"Program not responding" does not always mean that it is not opening or not doing what it's upposed to do. It can also mean that the program is - at the moment - so busy that it has no resources left to respond.
Have you waited for a while to see if Lr becomes "running" again?
I'd suggest to optimize your catalog (>File menu >Optimize catalog), unless you do a catalog backup regularly (optimizing is part of the backup).

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