Lion issues - Safari 5.1, iTunes 10.4.1, Preview, Numbers

I upgraded to Lion from Snow Leopard (early 2008 model iMac, 4GB, 2.4GHz) recently and when I did I could not log into Safari (hung when loading home page), iTunes would hang and Numbers would hang when trying to do anything. After searching the forums and troubleshooting I decided to run a clean install. I did and loaded my latest back up and all worked perfectly. Now, I just ran a software update and updated downloaded the latest security update and now I am back to where I was and Preview is now not opening. What gives??!!!! Help. I will do a clean install again if I must but surely don't want to have to keep doing this.

Repair your permissions, first. Then check your disk with Disk Utility. Finally, try deleting Preview preference file.

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