Lion, Spinning Ball for a few seconds at a time

Macbook Pro, Lion, 8Gig. I have frequent encounters with the spinning ball. Everything stops, the ball comes on, stays for several seconds, then back to life. During the episodes Safari, for example, is completely unresponsive. During the episodes, I can click on another application and switch to it.
This mac has been through several generations of OS X, and several different physical machines, using Migration Assistant at each shift.
Any help gratefully received!
-- Sally
Here is the EtreCheck result:
Hardware Information:
          MacBook Pro - model: MacBookPro6,2
          1 2.4 GHz Intel Core i5 CPU: 2 cores
          8 GB RAM
Video Information:
          NVIDIA GeForce GT 330M - VRAM: 256 MB
          Intel HD Graphics - VRAM: 288 MB
Startup Items:
          ProTec6b - Path: /Library/StartupItems/ProTec6b
          VirtualBox - Path: /Library/StartupItems/VirtualBox
System Software:
          Mac OS X 10.7.5 (11G63) - Uptime: 1 day 8:6
Disk Information:
          WDC WD5000BEVT-75ZAT0 disk0 : (500.11 GB)
                    disk0s1 (disk0s1) <not mounted>: 209.7 MB
                    Macintosh HD (disk0s2) /: 451.09 GB (47.76 GB free)
                    Recovery HD (disk0s3) <not mounted>: 650 MB
                    Snow Leopard (disk0s4) /Volumes/Snow Leopard: 48.03 GB (24.91 GB free)
          MATSHITADVD-R   UJ-898 
USB Information:
          Apple Computer, Inc. IR Receiver
          Apple Inc. Built-in iSight
          Apple Inc. BRCM2070 Hub
                    Apple Inc. Bluetooth USB Host Controller
          Apple Internal Memory Card Reader 7.95 GB
                    NO NAME (disk4s1) /Volumes/NO NAME: 7.94 GB (3.12 GB free)
          Apple Inc. Apple Internal Keyboard / Trackpad
FireWire Information:
Kernel Extensions:
          com.pgp.iokit.PGPwdeDriver          Version: 1.2.0d1
          at.obdev.nke.LittleSnitch          Version: 2.4.4
          com.paceap.kext.pacesupport.snowleopard          Version: 5.7.2
          com.AmbrosiaSW.AudioSupport          Version: 4.1.2
          org.virtualbox.kext.VBoxDrv          Version: 4.2.4
          org.virtualbox.kext.VBoxUSB          Version: 4.2.4
          org.virtualbox.kext.VBoxNetFlt          Version: 4.2.4
          org.virtualbox.kext.VBoxNetAdp          Version: 4.2.4
Problem System Launch Daemons:
             [not loaded]          ftp-proxy.plist
Problem System Launch Agents:
                 [failed] com.apple.mrt.uiagent.plist
Launch Daemons:
                 [loaded] at.obdev.littlesnitchd.plist
                 [loaded] com.adobe.fpsaud.plist
                 [loaded] com.adobe.SwitchBoard.plist
                 [loaded] com.ambrosiasw.ambrosiaaudiosupporthelper.daemon.plist
             [not loaded] com.barebones.bbedit.plist
                 [loaded] com.bombich.ccc.plist
                 [loaded] com.fitbit.fitbitd.plist
                 [loaded] com.google.keystone.daemon.plist
                 [loaded] com.microsoft.office.licensing.helper.plist
                 [loaded] com.pgp.framework.PGPwde.plist
                 [loaded] com.pgp.wde.pgpwded.plist
             [not loaded] com.qdea.syncproxhelper.plist
                 [loaded] PACESupport.plist
Launch Agents:
                 [loaded] at.obdev.LittleSnitchNetworkMonitor.plist
                 [loaded] at.obdev.LittleSnitchUIAgent.plist
             [not loaded] com.adobe.AAM.Updater-1.0.plist
                 [loaded] com.adobe.CS4ServiceManager.plist
                 [loaded] com.adobe.CS5ServiceManager.plist
                 [loaded] com.google.keystone.agent.plist
                 [loaded] com.pgp.pgpengine.plist
                 [loaded] com.wacom.wacomtablet.plist
                 [loaded] net.culater.SIMBL.Agent.plist
User Launch Agents:
                 [loaded] com.adobe.AAM.Updater-1.0.plist
                 [loaded] com.adobe.ARM.ad895013aeb33ea6e968d9fdc06c0eb42c7c2a5229d98d64ad002716.plist
             [not loaded] org.virtualbox.vboxwebsrv.plist
                 [loaded] ws.agile.1PasswordAgent.plist
User Login Items:
          iTunesHelper
          ScanSnap Manager
          ProfileReminder
          PGP Engine
3rd Party Preference Panes:
          A Better Finder Preferences
          Flash Player
          Java
          WacomTablet
Internet Plug-ins:
          AdobeExManDetect.plugin
          AdobePDFViewer.plugin
          AmazonMP3DownloaderPlugin.plugin
          AmazonMP3DownloaderPlugin101736.plugin
          Flash Player.plugin
          FlashPlayer-10.6.plugin
          googletalkbrowserplugin.plugin
          JavaAppletPlugin.plugin
          npgtpo3dautoplugin.plugin
          o1dbrowserplugin.plugin
          QuickTime Plugin.plugin
          SharePointBrowserPlugin.plugin
          WacomNetscape.plugin
          WacomTabletPlugin.plugin
User Internet Plug-ins:
          CitrixOnlineWebDeploymentPlugin.plugin
          WebEx64.plugin
Bad Fonts:
          None
Top Processes by CPU:
              15%          WebProcess
              10%          WindowServer
               8%          Finder
               5%          backupd
               4%          activitymonitord
               2%          SystemUIServer
               2%          EtreCheck
               1%          diskimages-helper
               1%          hidd
               1%          mds
Top Processes by Memory:
          1 GB          Adobe
          819 MB          WebProcess
          311 MB          Mail
          295 MB          Safari
          254 MB          mds
          188 MB          WindowServer
          147 MB          quicklookd
          115 MB          Finder
          74 MB          BBEdit
          66 MB          PluginProcess

Hey Sally,
We have an article that outlines a few troubleshooting steps if your Mac is running a bit slowly.
OS X Lion: If your Mac runs slowly
http://support.apple.com/kb/PH3915
If you find your Mac is running slowly, check any open applications to make sure they’re compatible with your computer. Or you may need to increase your hard disk space or repair your hard disk.
An application you’re using may require more memory than your computer has. To see how much memory your computer has, choose Apple menu > About This Mac. See the documentation that came with the application to find out what it requires. To find out how to increase your computer’s memory, see the documentation that came with it.
Quit any application that isn’t compatible with your computer. For example, an application may require a different processor or graphics card. See the documentation that came with the application to find out what it requires.
To see what processor your computer has, choose Apple menu > About This Mac.
To see what graphics card your computer has, choose Apple menu > About This Mac, click More Info, and then click Displays.
There might not be enough free disk space on your computer’s startup disk. To make disk space available, you can move files to another disk and then delete files you no longer need on the startup disk.Increase disk space
Quit any applications you’re not using.
If none of these suggestions work, you may need to repair your computer’s disk in Disk Utility.Repair a disk
Hope this helps,
David

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