Logic loses connection with midi interface

I just opened a brand new project where I loaded in my audio files, about 8 instruments. When I wanted to simply start playing the sound went off, and got the error message:
"Error while trying the synchronize audio and external device.
Sample Rate 38415 recognized.
Check conflict between Logic Pro and external device."
I many times lost connection and I have to restart the computer to see the midi interface again. I have the latest drivers installed. What else I could do?

Sorry, newbie question alert.
My Focusrite Saffire LE is a MIDI and audio
interface. It has a single MIDI in and out. I have 4
synth units I want to connect. Can I just go ...
in > thru > in > thru > in > thru > in > out
Theoretically, this should work and is the reason that
they are there. Now in a real world applicatioin you are
going to have to find out if in fact it will work. There
are a number of things that could be a problem but
I dont want to get you worrying about things that
might not happen. Just make sure you have good cables
and set up all your stuff in the Audio/Midi setup. If you
run into any problems try removing each device one at
a time to see if it is one piece that is causing the problem.
Have fun

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