Losing music when I sync to another iTunes

Hi - I'm wondering whether I can sync my ipod to more than one iTunes without wiping the exisitng content of my ipod?
is it possible to ensure that when, for instance, i plug my ipod into a mates itunes, it doesn't automatically sync all his tunes to my ipod and wipe what i already have on there?
a lot of the music i have was difficult to come by so am worried about taking the risk unless i know for sure that they won't disappear.
also, my existing tunes were ripped from Windows PC - does it make a difference if i sync from both Windows and Mac?
be great to hear some thoughts.
cheers

Hello and Welcome to Apple Discussions. 
To use with both a Mac and PC you'll need to have the iPod in FAT32 format:
http://docs.info.apple.com/article.html?artnum=61672
Then you need to disable Auto Syncing. Simply check "Manually manage music and videos" on the Summary pane in iTunes:
http://docs.info.apple.com/article.html?artnum=61675
cheers
mrtotes

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