Lost 30-40 gigs of files and settings

Today I suddenly lost a lot of files on my MacBook Pro 5,1. Examples of what I have lost:
Files:
All files on desktop exept one. No folders lost
All files in the default images folder. No folders lost
Settings lost:
Dock is back to default
No image as desktop background. Just skyblue solid colour.
Mailsettings are gone and the settings configurator starts asking on mail server and so on.
Safari is reset. Apple startpage, no bookmarks. Log of visited pages are ok.
Flash cant be installed. Installer hangs just before finish.
Itunes doesnt show any of my music. Starts up as new.
Time Machine asks which disk should be used as backup ( I have backup by the way )
Other:
Photoshops starts up, not Illustrator or Dreamweaver. Word  crashes during upstart. iOs Simulator starts up.
What i did mostly before this happed was installing Pear to use some php framwork. I also run some php to update a web CMS.
Is there anything I can do exept restore from Time Machine?
(this might be crossposted if i cant find a way to delete the copy post in the macbook pro forum. It belongs here I guess)

Disconnect all peripherals from your computer. Boot from your install disc & run Repair Disk from the utility menu. To use the Install Mac OS X disc, insert the disc, and restart your computer while holding down the C key as it starts up.
Select your language.
Once on the desktop, select Utility in the menu bar.
Select Disk Utility.
Select the disk or volume in the list of disks and volumes, and then click First Aid.
Click Repair Disk.
Restart your computer when done.
Repair permissions after you reach the desktop-http://docs.info.apple.com/article.html?artnum=25751 and restart your computer.
If you still cannot locate your files, uninstall Pear and all related files, use Spotlight to locate files.

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