Lots of Apps have suddenly stopped working...Help!

I've got an iBook G4 running 10.5.8 and for some reason a couple of weeks ago Safari stopped working. It would crash on launch every time. Then other apps started to follow, crashing on launch. I decided to update to 10.5.8 and Safari worked, but other apps still no longer work, like Firefox and 1Password and a bunch more. I've tried uninstalling some of the apps and reinstalling them, but I still have the same issues. I've tried running Onyx and fixing permissions, but still no dice. Also, every once in a while the computer won't come out of sleep. The computer will turn on, but the screen stays black and every now and then I get the blue screen of death for several hours. It feels like the iBook is on the way out. Any thoughts on how to save it?

I have a similar problem. And I really don't know how it happened. All was fine, I turned it off and when I switched it on next morning nothing worked.
Basically all my applications (apart from a dictionary, a music program and my system preferences) just bounce once and don't open. also, my desktop is empty, which it wasn't before the problem started. Even the finder won't open. But everything still seems to be on the hard disk because the music is still there and I can change the desktop picture choosing from my picture folders.
I tried to fix it with the instructions from the link you posted but didn't work. Thought it could be "Disk, permission, or cache corruption" or "Corrupted preferences other than those of the affected applications". Problem is that I can't run SMART diagnostics because I can't open the disc utility when putting in mac osx install disc. Also, I can't download anything to fix it because none of my browsers work.
Any ideas?

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