LR 1.4.1 Update caused LR to no longer work

I have installed LR 1.4.1 Update, it worked for a few weeks, but now when i try to load LR it gives error message - Microsoft Visual C++ Runtime error for lightroom.exe and says application has requested to terminate in unusual way, please contact applications support team, any ideas?
I have tried uninstalling then re-install. same problem
(Lightroom version 1 seems to work though if I just install that, but error then returns again if update applied)

I had exactly the same problem with LR 1.4.1 on Windows Vista Home Premium. After much searching and frustration, I had to re-install LR (and other software) as a different personality (user) on the PC, then log in as that user. I backed up everything first!
That was last August and it has been fine since. No idea why the problem started. Hope this helps.

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