LR4.2 Can't do any edits in Develop?

I'm selecting my photo (and it doesn't matter if I choose from Collections or Folders) and then go to Develop and none of the right hand panel will work. I can't select basic, tone curve, detail, -  nothing slides or moves not even the slider (that moves the panel up and down on the very right hand side). If I shut down LR and then come back in again it works. Has happened several times. I'm only using the trial version but wondered if that might be it.
Could there be a lock button I'm pressing some how?
Maybe this is a bug?

@Ronald,
I'm glad to know that you can get by on only 120 GB .  However, that's not my experience on Windows.  Admittedly, Mac and Mavericks in particular seem to manage memory a lot better than Win.  But I've been using PS since ver 4 and it's always been a huge memory drain. 
In CS6, I'm finding my scratch disk often exceeds 100 GB.  I have dedicated almost 300 GB to mine and it's still not enough for everything I do. But I know how to manage my resources so I can get by on what I have until new computers arrive.
Nancy O.

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