Mac Applications won't open on startup

Question

Whenever I start up my Macbook Pro, it's very slow when I log into my user account. It takes multiple attempts to open up programs such as Safari, Microsoft One Note, or Microsoft Word. The icon will pop up and bounce in my dock, then stop bouncing but not open. I have to right click and select "force quit" because it will tell me the application is not responding. It usually takes 4 or 5 tries before the application can start normally. If the laptop has been on a few hours, this usually won't happen.
I have tried logging in a Guest User account and everything opens up so quickly! Same thing when booting into Safe Mode and logging into my own user account. Rebooting normally, I still have this problem.
I tried following this thread but the fix seems to be user specific
All applications are up to date. This happened in Mountain Lion and now Yosemite (using 10.10 right now).
Specs:
MacBook Pro (13-inch, Mid 2009)
Processor 2.53 GHz Intel Core 2 Duo
Memory 4 GB 1067 MHz DDR3

Answer 1

Problem description:
Applications won’t open and won’t respond on latptop startup. It takes several openings and force quits before the application will actually open
EtreCheck version: 2.0.8 (95)
Report generated October 31, 2014 at 11:59:01 AM PDT
Hardware Information: ℹ️
  MacBook Pro (13-inch, Mid 2009) (Verified)
  MacBook Pro - model: MacBookPro5,5
  1 2.53 GHz Intel Core 2 Duo CPU: 2-core
  4 GB RAM Upgradeable
  BANK 0/DIMM0
  2 GB DDR3 1067 MHz ok
  BANK 1/DIMM0
  2 GB DDR3 1067 MHz ok
  Bluetooth: Old - Handoff/Airdrop2 not supported
  Wireless:  en1: 802.11 a/b/g/n
Video Information: ℹ️
  NVIDIA GeForce 9400M - VRAM: 256 MB
  Color LCD 1280 x 800
System Software: ℹ️
  OS X 10.10 (14A389) - Uptime: 1:41:13
Disk Information: ℹ️
  Hitachi HTS545025B9SA02 disk0 : (250.06 GB)
  S.M.A.R.T. Status: Verified
  EFI (disk0s1) <not mounted> : 210 MB
  Macintosh HD (disk0s2) /  [Startup]: 249.20 GB (82.29 GB free)
  Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
  HL-DT-ST DVDRW  GS23N 
USB Information: ℹ️
  Apple Inc. Built-in iSight
  Apple Internal Memory Card Reader
  Apple Inc. Apple Internal Keyboard / Trackpad
  Apple Computer, Inc. IR Receiver
  Logitech USB Receiver
  Apple Inc. BRCM2046 Hub
  Apple Inc. Bluetooth USB Host Controller
Gatekeeper: ℹ️
  Mac App Store and identified developers
Kernel Extensions: ℹ️
  /Library/Extensions
  [loaded] com.sophos.kext.sav (9.2.50 - SDK 10.8) Support
  [loaded] com.sophos.nke.swi (9.2.50 - SDK 10.8) Support
  /System/Library/Extensions
  [not loaded] com.AmbrosiaSW.AudioSupport (4.1.2 - SDK 10.7) Support
  [loaded] com.rim.driver.BlackBerryUSBDriverInt (0.0.74) Support
  [not loaded] com.rim.driver.BlackBerryUSBDriverVSP (0.0.74) Support
Launch Agents: ℹ️
  [not loaded] com.adobe.AAM.Updater-1.0.plist Support
  [loaded] com.divx.dms.agent.plist Support
  [loaded] com.divx.update.agent.plist Support
  [loaded] com.examsoft.softest.plist Support
  [loaded] com.oracle.java.Java-Updater.plist Support
  [running] com.rim.BBAlbumArtCacher.plist Support
  [running] com.rim.BBLaunchAgent.plist Support
  [running] com.sophos.uiserver.plist Support
  [loaded] org.macosforge.xquartz.startx.plist Support
Launch Daemons: ℹ️
  [loaded] com.adobe.fpsaud.plist Support
  [invalid?] com.adobe.SwitchBoard.plist Support
  [loaded] com.ambrosiasw.ambrosiaaudiosupporthelper.daemon.plist Support
  [loaded] com.ea.origin.ESHelper.plist Support
  [running] com.examsoft.softest.service.plist Support
  [loaded] com.microsoft.office.licensing.helper.plist Support
  [loaded] com.oracle.java.Helper-Tool.plist Support
  [running] com.orbicule.uc.plist Support
  [running] com.orbicule.uclocator.plist Support
  [running] com.rim.BBDaemon.plist Support
  [loaded] com.skype.skypeinstaller.plist Support
  [running] com.sophos.common.servicemanager.plist Support
  [loaded] org.macosforge.xquartz.privileged_startx.plist Support
User Launch Agents: ℹ️
  [loaded] com.adobe.AAM.Updater-1.0.plist Support
  [loaded] com.facebook.videochat.[redacted].plist Support
  [loaded] com.google.keystone.agent.plist Support
  [running] com.spotify.webhelper.plist Support
User Login Items: ℹ️
  iTunesHelper Application (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
  Dropbox Application (/Applications/Dropbox.app)
Internet Plug-ins: ℹ️
  DirectorShockwave: Version: 11.6.4r634 Support
  OVSHelper: Version: 1.1 Support
  Default Browser: Version: 600 - SDK 10.10
  AdobeExManDetect: Version: AdobeExManDetect 1.1.0.0 - SDK 10.7 Support
  Flip4Mac WMV Plugin: Version: 3.1.0.24   - SDK 10.8 Support
  Silverlight: Version: 5.1.30514.0 - SDK 10.6 Support
  FlashPlayer-10.6: Version: 15.0.0.189 - SDK 10.6 Support
  DivX Web Player: Version: 3.2.3.1164 - SDK 10.6 Support
  Flash Player: Version: 15.0.0.189 - SDK 10.6 Support
  QuickTime Plugin: Version: 7.7.3
  iPhotoPhotocast: Version: 7.0
  SharePointBrowserPlugin: Version: 14.4.5 - SDK 10.6 Support
  CouponPrinter-FireFox_v2: Version: 1.1.10 - SDK 10.6 Support
  JavaAppletPlugin: Version: Java 8 Update 25 Check version
User Internet Plug-ins: ℹ️
  Picasa: Version: 1.0 - SDK 10.4 Support
  RealPlayer Plugin: Version: (null) Support
Safari Extensions: ℹ️
  AdBlock
  Reddit Enhancement Suite
  Tumblr Savior
3rd Party Preference Panes: ℹ️
  Flash Player  Support
  Flip4Mac WMV  Support
  Growl  Support
  Java  Support
  Perian  Support
Time Machine: ℹ️
  Time Machine not configured!
Top Processes by CPU: ℹ️
      14% WindowServer
      7% Safari
      6% SophosWebIntelligence
      3% soagent
      2% com.apple.WebKit.Networking
Top Processes by Memory: ℹ️
  249 MB Safari
  82 MB com.apple.WebKit.WebContent
  53 MB com.apple.WebKit.Networking
  47 MB InterCheck
  43 MB soagent
Virtual Memory Information: ℹ️
  688 MB Free RAM
  902 MB Active RAM
  744 MB Inactive RAM
  533 MB Wired RAM
  5.06 GB Page-ins
  69 MB Page-outs