MAC book pro sluggish and locking up

I have a Mac book pro running Leopard 10.5.4 4GB Ram, 320GB hard drive with 136 GB free. Over the past two weeks, it is running slow and sluggish. When I open up an application I get the spinning wheel and it's lasting longer and longer.
I ran the disk utility to repair permissions (advice of a friend) and it has not improved the situation.
Does anyone know what else I can do?
Thanks,
Cestep6

Could you expand on your description of slow and sluggish? What application/s? Have you tried booting from your installer disk and running Repair Disk from Disk Utility?

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