Mac Pro 2010: Does it matter which HD Bay you run the OS from?

I have had a slight vibration problem emanating from the front grill of my 2010 Mac Pro. I thought it might have started since I installed the IcyDock adaptor which holds the OWC SSD (128GB) which I use as the boot and applications drive in Bay 1, but it may have been just a coincidence.  The vibration noise can be stopped by lifting the computer slightly off the ground with the front upper handle, or merely by pressing the grill between the two dvd/cd slots. It goes away on its own and then returns from time to time. In general, the machine runs very quietly.
I have rotated the 2 other WD drives that are installed between bays 2-4, but I was told on a forum that it is best to leave your boot drive in the  Bay1 for technical and operational reasons.  I doubt that moving this SSD drive would fix the on and off vibration problem but it would be worth a try to switch it if there were no risk to the machine's performance. 
Any advice would be appreciated.

In reading an older forum about vibrations, one person said that this vibration for him was coming from the superdrive casing. He mentioned that it might not be seated correctly and that if you just push on it and seat it correctly the vibration stops.
My vibration is coming from this area because, as I say above, if you just press on the metal grill between the superdrive slots, it stops. I'm just not sure what he means by press on the casing to re-seat it correctly. Would that be from the inside or from the outside pressing in. Not sure. It's not clear to me where or what the superdrive casing is.
In any case, the vibration seems to eventually subside and disappear if I just let it run its course..
An earlier forum member said something about Bay 1 as important for 32bit vs 64bit or something about a singular connection that only runs into Bay 1 and signals something to the rest of the system and whenever possible it is best for the boot drive to run out of Bay 1.
I was just thinking that perhaps because the SSD and the adaptor are so light, that maybe this contributed to the vibration in the front.
thanks for any other advice

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