Mac Pro 2010 USB issues

Hello,
This problem started about a week or two ago. I have a Mac Pro 2010 6-core model, and the USB ports on it (both front and back) have started to only "occasionally" work. First, my keyboard stopped working after waking from sleep, printing will stop midway through a page saying "lost connection to printer," and it is hit-or-miss if the computer will sync my iphone or not (but will still charge it for some reason...).
Restarting my computer *sometimes* temporarily fixes this issue, updating the OS temporarily fixed it too.
Right now, I am limited to using the 3 ports on my monitor for USB connections, and surprise! Printing stopped mid-way through a page, "lost connection."
Can anyone help me figure out what's going on before I can't even use the USB ports on my monitor? I can't think of anything that I've installed or attached to the ports recently that would cause any form of interference.
Thank you

Have you tried doing an SMC reset?

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