Mac suddenly slow and laggy. Memory is not an issue. Can anyone please review my etrecheck report?

Question

It went from running fine, to being slow and laggy overnight. Memory or HD space is not an issue. Can someone please review the following report that etrecheck ran for me, and let me know of any potential problems they see.
EtreCheck version: 1.9.12 (48)
Report generated July 19, 2014 10:09:38 AM EDT
Hardware Information:
  MacBook Pro (13-inch, Mid 2012) (Verified)
  MacBook Pro - model: MacBookPro9,2
  1 2.9 GHz Intel Core i7 CPU: 2 cores
  8 GB RAM
Video Information:
  Intel HD Graphics 4000 - VRAM: 512 MB
  Color LCD 1280 x 800
System Software:
  Mac OS X 10.7.5 (11G63b) - Uptime: 0 days 1:36:5
Disk Information:
  TOSHIBA MK7559GSXF disk0 : (750.16 GB)
  disk0s1 (disk0s1) <not mounted>: 209.7 MB
  Macintosh HD (disk0s2) / [Startup]: 749.3 GB (641.69 GB free)
  Recovery HD (disk0s3) <not mounted>: 650 MB
  HL-DT-ST DVDRW  GS31N 
USB Information:
  Apple Inc. BRCM20702 Hub
  Apple Inc. Bluetooth USB Host Controller
  Apple Computer, Inc. IR Receiver
  Apple Inc. Apple Internal Keyboard / Trackpad
  Apple Inc. FaceTime HD Camera (Built-in)
Thunderbolt Information:
  Apple, Inc. MacBook Pro
Configuration files:
  /etc/hosts - Count: 20
Kernel Extensions:
  [loaded] com.protech.NoSleep (1.3.1 - SDK 10.8) Support
Launch Daemons:
  [loaded] com.adobe.fpsaud.plist Support
  [loaded] com.google.keystone.daemon.plist Support
  [loaded] com.macpaw.CleanMyMac2.Agent.plist Support
  [loaded] com.microsoft.office.licensing.helper.plist Support
  [loaded] com.oracle.java.Helper-Tool.plist Support
  [loaded] org.macosforge.xquartz.privileged_startx.plist Support
Launch Agents:
  [not loaded] com.adobe.AAM.Updater-1.0.plist Support
  [failed] com.adobe.AdobeCreativeCloud.plist Support
  [loaded] com.google.keystone.agent.plist Support
  [loaded] com.oracle.java.Java-Updater.plist Support
  [loaded] org.macosforge.xquartz.startx.plist Support
User Launch Agents:
  [failed] com.apple.CSConfigDotMacCert-[...]@me.com-SharedServices.Agent.plist
  [loaded] com.macpaw.CleanMyMac2Helper.diskSpaceWatcher.plist Support
  [loaded] com.macpaw.CleanMyMac2Helper.scheduledScan.plist Support
  [loaded] com.macpaw.CleanMyMac2Helper.trashWatcher.plist Support
  [running] com.spotify.webhelper.plist Support
User Login Items:
  Flux
Internet Plug-ins:
  JavaAppletPlugin: Version: Java 7 Update 40 Check version
  o1dbrowserplugin: Version: 5.4.2.18903 Support
  Unity Web Player: Version: UnityPlayer version 4.1.2f1 Support
  FantashowPlugin: Version: FantashowPlugin 1.0.0.0 - SDK 10.7 Support
  AdobeAAMDetect: Version: AdobeAAMDetect 2.0.0.0 - SDK 10.7 Support
  FlashPlayer-10.6: Version: 14.0.0.145 - SDK 10.6 Support
  Silverlight: Version: 5.1.10411.0 - SDK 10.6 Support
  Flash Player: Version: 14.0.0.145 - SDK 10.6 Support
  QuickTime Plugin: Version: 7.7.1
  googletalkbrowserplugin: Version: 5.4.2.18903 Support
  SharePointBrowserPlugin: Version: 14.2.3 - SDK 10.6 Support
  DirectorShockwave: Version: 12.0.2r122 - SDK 10.6 Support
Safari Extensions:
  Open in Internet Explorer: Version: 1.0
  Searchme: Version: 1.3
Audio Plug-ins:
  iSightAudio: Version: 7.7.1 - SDK 10.7
iTunes Plug-ins:
  Quartz Composer Visualizer: Version: 1.3 - SDK 10.7
User iTunes Plug-ins:
  TuneUp Visualizer: Version: Unknown
User Internet Plug-ins:
  thinkorswim plugin_x86_64: Version: thinkorswim_x86_64 1.0.0.0 - SDK 10.7 Support
  tossc plugin_x86_64: Version: TOS Sharing Center plugin_x86_64 1.0.0.0 - SDK 10.7 Support
3rd Party Preference Panes:
  Flash Player  Support
  Java  Support
Time Machine:
  Time Machine not configured!
Top Processes by CPU:
      3% WindowServer
      0% opendirectoryd
Top Processes by Memory:
  82 MB mds
  49 MB Finder
  41 MB HP_Photosmart_C4400_series
  33 MB SystemUIServer
  33 MB WindowServer
Virtual Memory Information:
  6.42 GB Free RAM
  677 MB Active RAM
  206 MB Inactive RAM
  730 MB Wired RAM
  366 MB Page-ins
  0 B Page-outs

Answer 1

First, if you don't already have a current backup, back up all data immediately.
When you have the problem, note the exact time: hour, minute, second.   
These instructions must be carried out as an administrator. If you have only one user account, you are the administrator.
Launch the Console application in any of the following ways:
☞ Enter the first few letters of its name into a Spotlight search. Select it in the results (it should be at the top.)
☞ In the Finder, select Go ▹ Utilities from the menu bar, or press the key combination shift-command-U. The application is in the folder that opens.
☞ Open LaunchPad. Click Utilities, then Console in the icon grid.
The title of the Console window should be All Messages. If it isn't, select
          SYSTEM LOG QUERIES ▹ All Messages
from the log list on the left. If you don't see that list, select
          View ▹ Show Log List
from the menu bar at the top of the screen.
Each message in the log begins with the date and time when it was entered. Scroll back to the time you noted above. Select the messages entered from then until the end of the episode, or until they start to repeat, whichever comes first. Copy the messages to the Clipboard by pressing the key combination command-C. Paste into a reply to this message by pressing command-V.
The log contains a vast amount of information, almost all of it useless for solving any particular problem. When posting a log extract, be selective. A few dozen lines are almost always more than enough.
Please don't indiscriminately dump thousands of lines from the log into this discussion.
Please don't post screenshots of log messages—post the text.
Some private information, such as your name, may appear in the log. Anonymize before posting.