Macbook Pro 10.1 - suddenly no sound (X'd out) in flash videos (Youtube)

Title says it all. System is 10.8.3, all possible system updates installed and relevant software including latest available version of Adobe flash player.
Youtube videos in browsers (Safari and Firefox) show an X'd volume control and have no sound. All system sounds and other video coming from machine (eg iTunes) perfectly fine.
Problem exists for all sound outputs, ie internal speakers, USB out sound and Thunderbolt out (cinema display).
Have tried several restarts and checked all preference settings in browsers.
Sound settings in system preferences are correct (not muted).
Have tried adjustments in the audio midi setttings with no luck.
Have tried PRAM and SMC resets, no dice.
This suddenly happened in the last week or so. Previously, this issue did not exist, atlhough I don't know exactly when it might have cropped up since I don't watch that much Youtube.
Pulling out my hair with this issue.
Any insight appreciated!

Quit Safari.
Update Flash Player.
System Preferences > Other > Flash Player > Advanced > Updates > "Check Now"
Follow the prompts.
Relaunch Safari.

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