MacBook Pro (10.7.3) not shutting down after updating to latest iTunes

This is a bit of a strange one, and after searching high and low, I haven't seen any other references to it, so...here goes:
I'm working on a MacBook Pro (13-inch, Mid 2010) running OS X 10.7.3, and the complaint is this: the system will not shut down or eject a connected iPod (classic) or smartphone (Verizon Android phone) after updating to the latest version of iTunes.
I've been troubleshooting this for several days now, and I've tried the following:
1. Created a new admin account and tested from there. No change.
2. Created a backup image of the hard drive, erased & reinstalled 10.7, created temp admin account - issue resolved, but iTunes library unable to open because it was modified by a newer version of iTunes.
3. Ran software update to bring system current (as of 20 April 2012)
4. Issue reappears after software update.
5. Reinstalled 10.7.3 from Recovery partition.
6. Again, issue resolved, but unable to open iTunes library modified by newer version.
7. Update iTunes, issue returns.
I actually did several variations of the erase & install routine, as well as several admin accounts, but the basic gyst of it is that after updating iTunes, the system hangs at the spinning gear on shutdown every single time.
The version of iTunes that is reinstalled with Lion is 10.5.1. I don't know which version between that and 10.6.1 is causing the problem.
Not sure where to go from here, so I figured I'd throw it out to the community.
Thanks.

Well, after throwing my hands up in the air, I returned the MacBook Pro and iPod classic to their owner because I'd held onto them for over a week trying to troubleshoot the issue with no success.
Two days later, she contacted me and told me her iPod was the culprit -- it had some bad sectors on the hard drive. I had thought to check that, but she had data on the iPod that wasn't backed up anywhere, so I back-burnered that until later.
Glad to see I'm not going insane, though. ;^)

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