MacBook Pro 17-inch issues with Mavericks

Question

I have just installed (twice) the new Mavericks on my MacBook Pro 17-Inch from late 2011. Sporting the 2.5 GHz Intel Core i7 with 4GB of 1333 MHz DDR3 RAM. Intel HD Graphics 3000 384 MB.
All that being said, it's running a bit slow (seems to be a commin issue). But that's not why I'm posting. My question is a permissions issue. I have since run permissions fixes since installing, and yet, I'm being told, for example from iTunes, "The folder "iTunes" is on a locked disk or you do not have write permission for this folder." Then iTunes, expectedly, just shuts down. And for Photoshop CS5, "An unexpected and unrecoverable problem has occurred. Photoshop will now exit". InDesign opens, but so slowly, it's effectively useless. I go to quit out, and it hangs up trying to shut down. Illustrator is the same; opens slowly, hard to work with, seems to crash while shutting down. My first install, Safari wouldn't even launch. Now it seems to launch okay and function okay.
So, anyone have any idea why my permissions seem to be borked?
As an aside, before I upgraded, I did have problems with preferences being saved in Safari and LinoType font utility.
Thanks for any input that might help me out. I have lots of freelance art to do, and right now, no machine to do it with.
— Nix

Answer 1

If you're having trouble making changes to files that are inside your home folder (represented by a house icon in the sidebar of a Finder window), or if you can't get changes to the settings of an application to stick, then please see below.
Back up all data.
This procedure will unlock all your user files (not system files) and reset their ownership and access-control lists to the default. If you've set special values for those attributes on any of your files, they will be reverted. In that case, either stop here, or be prepared to recreate the settings if necessary. Do so only after verifying that those settings didn't cause the problem. If none of this is meaningful to you, you don't need to worry about it.
Step 1
If you have more than one user, and the one in question is not an administrator, then go to Step 2.
Triple-click anywhere in the following line on this page to select it:
{ sudo chflags -R nouchg,nouappnd ~ $TMPDIR..; sudo chown -R $UID:staff ~ $_; sudo chmod -R u+rwX ~ $_; chmod -R -N ~ $_; } 2>&-
Copy the selected text to the Clipboard by pressing the key combination command-C.
Launch the built-in Terminal application in any of the following ways:
☞ Enter the first few letters of its name into a Spotlight search. Select it in the results (it should be at the top.)
☞ In the Finder, select Go ▹ Utilities from the menu bar, or press the key combination shift-command-U. The application is in the folder that opens.
☞ Open LaunchPad. Click Utilities, then Terminal in the icon grid.
Paste into the Terminal window by pressing command-V. I've tested these instructions only with the Safari web browser. If you use another browser, you may have to press the return key after pasting.
You'll be prompted for your login password. Nothing will be displayed when you type it. You may get a one-time warning to be careful. If you don’t have a login password, you’ll need to set one before you can run the command. If you see a message that your username "is not in the sudoers file," then you're not logged in as an administrator.
The command may take a few minutes to run, or perhaps longer if you have literally millions of files in your home folder. Wait for a new line ending in a dollar sign ($) to appear, then quit Terminal.
Step 2 (optional)
Take this step only if you have trouble with Step 1, if it frightens you, or if it doesn't solve the problem.
Start up in Recovery mode. When the OS X Utilities screen appears, select
Utilities ▹ Terminal
from the menu bar. A Terminal window will open.
In the Terminal window, type this:
res
Press the tab key. The partial command you typed will automatically be completed to this:
resetpassword
Press return. A Reset Password dialog will open. You’re not going to reset a password.
In the dialog, select the startup volume ("Macintosh HD," unless you gave it a different name) if it's not already selected.
Select your username from the menu labeled Select the user account if it's not already selected.
Under Reset Home Directory Permissions and ACLs, click the Reset button.
Select
 ▹ Restart
from the menu bar.