MacBook Pro freezes when loading applications

My 15" MacBook Pro doesn't load applications - it boots, logs in, and I can get to my desktop.. however, the colored pinwheel comes up, spins for about a minute and then stops. When I try to click anything (from the dock, Macintosh HD, etc.. the pinwheel comes back up, the icon bounces, and nothing happens, or, the app loads veerrrry slow (i.e it takes 15 minutes to load Firefox..)). I can run in Safe Mode, but can't access my network, printers, etc.. Any help? Thanks!!

Hi Jamie,
Have you tried Repairing Permissions? Go to Applications-Utilities-Disk Utility. Highlight your OS, on the left and click on Repair Permissions below.
If that doesn't help, there is no way to know why this is happening. To me it sounds like software and not hardware related. I would backup my data, and do a clean installation. After that I would run Software Update, and then lastly Repair Permissions. Then transfer your data back.

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    The next time you have the problem, note the exact time: hour, minute, second.
    If you have more than one user account, these instructions must be carried out as an administrator.
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