MacBook won't boot from new hard drive.

I'm trying to upgrade my hard drive, but my macbook will not boot to the new hard drive. I have erased and cloned the hard drive about three times now, using both Carbon Copy Cloner and SuperDuper. It won't boot while it is in the macbook and it won't boot from an external hard drive case. All I get to is the screen with the mac logo and the spinning wheel. I have made sure the drive is GUID formatted, but it still doesn't work. When I put the new drive in an external case and plug it into the USB port of my macbook I can see and access everything on the drive. Can somebody please tell what I am doing wrong?
By the way the new hard drive is a 500gb western digital Scorpio blue drive.

I got a new hard drive recently 500gb seagate. I followed the directions on this page http://www.ehow.com/how2063795format-hard-drive-mac-os.html , Mine was a little more complicated since i had 2 partitions windows and mac on mine. Initially the process took a day and it started getting to the same thing as yours where it would get to the mac logo and not find the hard drive. I reformatted several times before i got to the point where i could boot up.Eventually I just figured out all the info was there the drive was formatted i could boot into windows 7 but not mac. So i put old hard drive back in the computer booted up with that. Attached new hard drive via usb in external case i was trying to put in the mac. I was able not to boot up but it would show the drives that have been formatted into the new drive and i simply copied my existing Disk by dragging it onto the new hard drive. Than turn off your mac keep your hard drive plugged in. Press and hold the option key in start up and you should see the 2 seperate hard drives and be able to boot into the new one. Was a long process for me took several complete deletes of the new hard drive and reformatting before it would work. once you get to the mac logo and spinning wheel its just saying mac cant find your boot up disk though. Sorry its confusing a bit any questions email me.

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