Macbook won't detect USB input devices

Hi everyone!
I'm desperately browsing the forum threads here for some help but after resetting everything resetable and after all recommended software updates, I still can't get my USB ports to recognize my external mouse/keyboard (Logitech S530 Desktop). Of course, I have also tried several other mice (also wired) but it didn't work either. Though, external HDs and IPod work fine. I quite doubt that it's a hardware problem because after formatting and reinstalling the OS, the ports were working again until I have carried out all the software updates (firmware and so on...). Could it be a driver conflict? Is there someone with the same problem?
I'd really appreciate your help!!!
MacBook (Black)   Mac OS X (10.4.7)  

I have had a problem that is a little similar. After leaving my computer on and not using it for a few hours I return to find my input devices (keyboard and mouse) not responding. the computer is still perfectly functional, but the USB devices do not work. I have to restart to get them to work again.
Any ideas? It's happened 3-4 times in the past few weeks since I got it. I thought it was just being iffy, but this is a little worrying.
thanks!

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