Mail 2.1.3 cannot quit, cannot synch, goes to endless beachball

Hi,
maybe this issue has been posted already but I cannot understand what to do to fix it.
Issue:
When I open Mail 2.1.3 I cannot see any message unless I select View Messages in the Window tab.
I cannot synch the POP account with my gmail account, the beachball appears and runs endlessly with completing the synch task
I cannot select the General tab in Preferences. The beachball appears and runs forever and I have to force quit the application
When I hit Quit nothing happens, I have to force quit to close it.
I have enough memory space on my HD
I have run HD validation and it is OK
Help, when do I have to do to fix this?
Do i have to reinstall Mail ?
Will I lose the emails currently in Mail?
THANKS to anyone who can help me.
Betty

Hi Betty, and a warm welcome to the forums!
Could be many things, we should start with this...
"Try Disk Utility
1. Insert the Mac OS X Install disc that came with your computer, then restart the computer while holding the C key.
2. When your computer finishes starting up from the disc, choose Disk Utility from the Installer menu. (In Mac OS X 10.4 or later, you must select your language first.)
*Important: Do not click Continue in the first screen of the Installer. If you do, you must restart from the disc again to access Disk Utility.*
3. Click the First Aid tab.
4. Click the disclosure triangle to the left of the hard drive icon to display the names of your hard disk volumes and partitions.
5. Select your Mac OS X volume.
6. Click Repair. Disk Utility checks and repairs the disk."
http://docs.info.apple.com/article.html?artnum=106214
Then Safe Boot, (holding Shift key down at bootup), run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions, then I'd backup these two Mail folders, by right clicking on them in the Finder, then choose Archive/Compress.
Users/YourUserName/Library/Mail
Users/YourUserName/Library/Mail Downloads
Right click on that Mail folder, choose archive, you'll get everything in the folder, and the folder itself in a file called Mail.zip, move it to a safe place, same for the Mail Downloads folder... only the plist is separate.
Then In your home folder, try moving this +folder & file+ to the Desktop...
/Users/YourUserName/Library/Caches/Mail
Move to the Desktop...
/Users/YourUserName/Library/Mail/Envelope Index
Reboot when complete.

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