Mail Application won't open despite software updates and restarts. Can anyone help?

Hi~
Having major problems with Mail today. Updated all of my software on my Macbook pro and then tried to open Mail which was not responding before the updates. Now it wont even open despite having all software up to date and having tried restarting the computer over and over. When I go to open it it immediately says not responding when I open the Force Quit window. Doesn't matter how long I leave it open. When I try to restart, restart stops as Mail is not responding. have to force quit and start over. Can't access my emails. Anyone have any ideas? PS - I am not very tech savvy, so if you do have ideas, please be clear in how to execute. Thanks in advance!

Had the same problem, I installed the following update and it fixed it for me:
http://support.apple.com/kb/DL1600
Hope this helps!

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