Mail box not open

i would suggest you do the following in order:
1) shut down, start again, then see if you can launch mail
if that does not help then
2) delete the com.apple.mail.plist file located in homefolder/library/preferences, then see if you can launch mail
if that does not help then
3) restart the computer, immediately upon hearing the restart chime, then hold down the shift key until you get past a screen where you may see safe boot written in red and until you get to the log in screen or to the desktop, then immediately after that restart normally, then launch mail
if that does not help then
4) do you have plug ins or input managers installed with mail by any chance? if so then disabled/get rid of them - these are located in homefolder/library/mail/bundles. i would look at growl, which has been know to trigger repeated crashes in mail.
let me know and hope this helps

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