Mail Erased Accounts and Now the System is Acting Strange

I just reinstalled Tiger after it crashed last week. A few days ago my wife was prompted to do something when I wasn't around and it wiped out our two Mail accounts. I reinstalled the accounts but ever since odd things are happening.
1) One account still can not send, and the other only sends after I again reset the account.
2) The fonts for Mail, the best I can describe don't look right, I have adjusted them in preferences and got them to look better but still something is wrong.
3) Other fonts have changed. Desktop icon fonts are thick white with a black outline and all fonts in HD have gone into some narrow font.
This is more annoying than anything, I just want to know if this is a symptom of a bigger problem.
Thanks!

Hi clumsymonster, and a warm welcome to the forums!
Safe Boot from the HD, (holding Shift key down at bootup), run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions, test if the Finder/Desktop/Dock works right while in Safe Mode, reboot when complete, test again.
On the Mail thing...
Quit Mail, then In your home folder, try moving this +folder & file+ to the Desktop then reboot...
/Users/YourUserName/Library/Caches/Mail
Move to the Desktop...
/Users/YourUserName/Library/Mail/Envelope Index
You can always move them back if it doesn't help.

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