Mail Flow between 2 AD Sites stops and EMC unavailable on the local server

Hello All,
I'm hoping you can help me find a solution to this recurring problem.
SYMPTOMS :
Mail Flow between 2 EXCH2010 servers in 2 different AD Sites (separate time zones) stops suddenly with no messages in the Event Viewer or exchange logs.
When this happens the EMC is unavailable on the local server : Error message Connection attempt to http://<servername> with the help of "Kerberos" failed : The connection to the remote server failed with the following error : Access Refused
Same error when opening Exchange Powershell
On the OTHER server (ie the one I can connect to in Site 2) I can :
1 - Connect to the first server using EMC with no problems
2 - Using mail queue viewer pointed at the server in Site 2 I can see the following error for email directed to the server in Site 1 : 451 4.4.0 Primary target address responded with: "235 00000804YIIF/<load of alphanumeric characters 80 or so long>
RECOVERY :
A reboot of the server allows access to the EMC and Powershell and mail flow once again starts.... until the next time
OTHER INFORMATION :
When in the above state, ran Exchange Management Troubleshooter which finds errors but cannot identify them : "Unknown Error" then stops !
Ran ExBPA : turns up nothing
Currently needing to reboot every day or so.
I though maybe the local server had a problem with resolving itself correctly, did some troubleshooting around that and turned up nothing. Even added itself to its hosts file in order to resolve its IP : Changed nothing.
Searched on the above error 451 4.4.0 etc and turned up nothing useful.
I think the Kerberos error is telling, but I haven't turned anything up during a search yet.
Any ideas ?
Please AMA if you need more info or clarification.
Matthew

Hello,
When the issue happens, can you telent the target server successfully?
Please refer to the following KB article to see if it helps:
https://support2.microsoft.com/kb/979175?wa=wsignin1.0
Thanks,
Please remember to mark the replies as answers if they help and unmark them if they provide no help. If you have feedback for TechNet Subscriber Support, contact
[email protected]
Simon Wu
TechNet Community Support

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