Mail freezes on opening - two different machines on same day

Trying to do some remote IT support for my coworkers with an odd Mail.app issue that can't be coincidental.
Both machines are MacBook Pros running 10.4.11 and should be fully updated. Both users are using Mail.app with POP e-mail through our domain name server.
When either/or opens their Mail application while connected to the internet they get a spinning beach ball and are unable to use mail. The odd things is, both users are on different sides of the country and the problem started at the same time with both of them. This problem does not occur when the machines are not connected to the net.
I figured that either they both received an e-mail that is blocking the system or have some conflict with their Verizon WAN cards. We have taken the following steps with one of the machines:
1. Start mail with the Shift key held down to deselect the mailboxes. Closed the preview window.
This does not have any effect while the machines are connected - there is still the same problem.
2. Delete the preferences file and reenter all account info.
This also had no effect.
Any thoughts on possible causes or solutions?
Thanks!
Chuck

Verify/repair the startup disk (not just permissions), as described here:
The Repair functions of Disk Utility: what's it all about?
Go to Apple Menu > System Preferences > Network, choose Network Port Configurations from the Show popup menu, and make sure that the configuration used to connect to Internet appears at the top of the list. Leave checked (enabled) only the port configuration needed to connect to Internet and Built-in Ethernet (in that order if not the same), uncheck (disable) the rest of network port configurations, and see whether that helps — if it doesn’t, turn ON again the ones you want enabled.
Try launching Mail under the following conditions (you may need to force quit it first if it’s running) and post back with your observations:
A. Holding the Shift (⇧) key down until the main window appears. This tells Mail to not select any mailboxes or load any messages upon start up.
B. With no Internet connection.
You may also try trashing the Mail cache:
1. (Force) Quit Mail if it’s running.
2. In the Finder, go to ~/Library/Caches/.
3. Locate the Mail cache folder (not to be confused with the ~/Library/Mail folder where all your mail is stored) and move it to the Desktop (to be deleted after opening Mail and checking that all your mail is there, i.e. after making sure that you didn’t remove the ~/Library/Mail folder by mistake).
Note: For those not familiarized with the ~/ notation, it refers to the user’s home folder. That is, ~/Library is the Library folder within the user’s home folder, i.e. /Users/username/Library.

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