MAIL ICON NO LONGER OPENS MAIL

I can no longer open up my mail.  When I select the icon it will activate for a few seconds then goes off.  No error message given just won't open.  I also noticed I can not move any of the items in the dock.  Can't rearrainge them or move them to trash.  All icons are frozen where they are.  All programs except for mail will open.  Have tried closing all programs and restarting but that does not fix the problem.  Any suggestions?

You don't say what OS you're running but you are in the Mountain Lion section.
I would start by opening terminal (applications/utility) and type the following
rm ~/Library/Preferences/com.apple.dock.plist
rm ~/Library/Mail/V2/MailData/Envelope\ Index
I would then shutdown and reboot into recovery (command-R at the boot chime) and select my boot drive, then select repair.
After repair comes back clean, you can reboot normally.

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