Mail is real slow

When moving between e-mails it takes 6 seconds to show the new e-mail.  To delete the e-mail it takes 10 seconds.  What can be done to speed this up?

Please follow these directions to delete the Mail "sandbox" folder.
Back up all data.
Quit Mail.
Triple-click the line below to select it:
~/Library/Containers/com.apple.mail
Right-click or control-click the highlighted line and select
Services ▹ Reveal
from the contextual menu. A Finder window should open with a folder named "com.apple.mail" selected. If it does, move the selected folder — not just its contents — to the Desktop. Leave the Finder window open for now.
Relaunch Mail and test. If the problem is resolved, you'll have to recreate some of your Mail settings. You can then delete the folder you moved and close the Finder window. If you still have the problem, quit Mail again and put the folder back where it was, overwriting the one that may have been created in its place. Post your results.
Caution: If you change any of the contents of the sandbox, but leave the folder itself in place, Mail may crash or not launch at all. Deleting the whole sandbox will cause it to be rebuilt automatically.

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    qmgr_fudge_factor = 100
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    queue_run_delay = 900s
    queue_service_name = qmgr
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    receive_override_options =
    recipient_bcc_maps =
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    reject_code = 554
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    relayhost =
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    resolve_dequoted_address = yes
    resolve_null_domain = no
    rewrite_service_name = rewrite
    sample_directory = /usr/share/doc/postfix/examples
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    sender_bcc_maps =
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    showq_service_name = showq
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    smtp_data_done_timeout = 600s
    smtp_data_init_timeout = 120s
    smtp_data_xfer_timeout = 180s
    smtp_defer_if_no_mx_address_found = no
    smtp_destination_concurrency_limit = $default_destination_concurrency_limit
    smtp_destination_recipient_limit = $default_destination_recipient_limit
    smtp_enforce_tls = no
    smtp_helo_name = $myhostname
    smtp_helo_timeout = 300s
    smtp_host_lookup = dns
    smtp_line_length_limit = 990
    smtp_mail_timeout = 300s
    smtp_mx_address_limit = 0
    smtp_mx_session_limit = 2
    smtp_never_send_ehlo = no
    smtp_pix_workaround_delay_time = 10s
    smtp_pix_workaround_threshold_time = 500s
    smtp_quit_timeout = 300s
    smtp_quote_rfc821_envelope = yes
    smtp_randomize_addresses = yes
    smtp_rcpt_timeout = 300s
    smtp_rset_timeout = 120s
    smtp_sasl_auth_enable = no
    smtp_sasl_password_maps =
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    smtp_sasl_tls_verified_security_options = $var_smtp_sasl_tls_opts
    smtp_send_xforward_command = no
    smtp_skip_5xx_greeting = yes
    smtp_skip_quit_response = yes
    smtp_starttls_timeout = 300s
    smtp_tls_CAfile =
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    smtpd_etrn_restrictions =
    smtpd_expansion_filter = \t\40!"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\\]^_`abcdefghi jklmnopqrstuvwxyz{|}~
    smtpd_hard_error_limit = 20
    smtpd_helo_required = no
    smtpd_helo_restrictions =
    smtpd_history_flush_threshold = 100
    smtpd_junk_command_limit = 100
    smtpd_noop_commands =
    smtpd_null_access_lookup_key =
    smtpd_policy_service_max_idle = 300s
    smtpd_policy_service_max_ttl = 1000s
    smtpd_policy_service_timeout = 100s
    smtpd_proxy_ehlo = $myhostname
    smtpd_proxy_filter =
    smtpd_proxy_timeout = 100s
    smtpd_pw_server_security_options = login,plain,cram-md5,gssapi
    smtpd_recipient_limit = 1000
    smtpd_recipient_overshoot_limit = 1000
    smtpd_recipient_restrictions = check_recipient_access hash:/etc/postfix/access, permit_mynetworks, permit_sasl_authenticated, reject_invalid_hostname, reject_non_fqdn_sender, reject_non_fqdn_recipient, reject_unknown_sender_domain, reject_unauth_destination, check_sender_access hash:/etc/postfix/whiteList
    smtpd_reject_unlisted_recipient = yes
    smtpd_reject_unlisted_sender = no
    smtpd_restriction_classes =
    smtpd_sasl_application_name = smtpd
    smtpd_sasl_auth_enable = yes
    smtpd_sasl_exceptions_networks =
    smtpd_sasl_local_domain =
    smtpd_sasl_security_options = noanonymous
    smtpd_sasl_tls_security_options = $smtpd_sasl_security_options
    smtpd_sender_login_maps =
    smtpd_sender_restrictions =
    smtpd_soft_error_limit = 10
    smtpd_starttls_timeout = 300s
    smtpd_timeout = 300s
    smtpd_tls_CAfile =
    smtpd_tls_CApath =
    smtpd_tls_ask_ccert = no
    smtpd_tls_auth_only = no
    smtpd_tls_ccert_verifydepth = 5
    smtpd_tls_cert_file = /etc/certificates/mail.myDomain.com.crt
    smtpd_tls_cipherlist =
    smtpd_tls_dcert_file =
    smtpd_tls_dh1024_param_file =
    smtpd_tls_dh512_param_file =
    smtpd_tls_dkey_file = $smtpd_tls_dcert_file
    smtpd_tls_key_file = /etc/certificates/mail.myDomain.com.key
    smtpd_tls_loglevel = 2
    smtpd_tls_received_header = no
    smtpd_tls_req_ccert = no
    smtpd_tls_session_cache_database =
    smtpd_tls_session_cache_timeout = 3600s
    smtpd_tls_wrappermode = no
    smtpd_use_pw_server = yes
    smtpd_use_tls = yes
    soft_bounce = no
    stale_lock_time = 500s
    strict_7bit_headers = no
    strict_8bitmime = no
    strict_8bitmime_body = no
    strict_mime_encoding_domain = no
    strict_rfc821_envelopes = no
    sun_mailtool_compatibility = no
    swap_bangpath = yes
    syslog_facility = mail
    syslog_name = postfix
    tls_daemon_random_bytes = 32
    tls_daemon_random_source =
    tls_random_bytes = 32
    tls_random_exchange_name = ${config_directory}/prng_exch
    tls_random_prng_update_period = 60s
    tls_random_reseed_period = 3600s
    tls_random_source =
    trace_service_name = trace
    transport_maps =
    transport_retry_time = 60s
    trigger_timeout = 10s
    undisclosed_recipients_header = To: undisclosed-recipients:;
    unknown_address_reject_code = 450
    unknown_client_reject_code = 450
    unknown_hostname_reject_code = 450
    unknown_local_recipient_reject_code = 550
    unknown_relay_recipient_reject_code = 550
    unknown_virtual_alias_reject_code = 550
    unknown_virtual_mailbox_reject_code = 550
    unverified_recipient_reject_code = 450
    unverified_sender_reject_code = 450
    verp_delimiter_filter = -=+
    virtual_alias_domains = $virtual_alias_maps
    virtual_alias_expansion_limit = 1000
    virtual_alias_maps = hash:/etc/postfix/virtual,hash:/var/mailman/data/virtual-mailman
    virtual_alias_recursion_limit = 1000
    virtual_destination_concurrency_limit = $default_destination_concurrency_limit
    virtual_destination_recipient_limit = $default_destination_recipient_limit
    virtual_gid_maps =
    virtual_mailbox_base =
    virtual_mailbox_domains = hash:/etc/postfix/virtual_domains
    virtual_mailbox_limit = 51200000
    virtual_mailbox_lock = fcntl
    virtual_mailbox_maps =
    virtual_minimum_uid = 100
    virtual_transport = lmtp:unix:/Volumes/Mail/imap/socket/lmtp
    virtual_uid_maps =

    I do have a few Windows clients. They have up to date virus protection but they could very well be infected with some malware. I haven't had the chance to run SpyBot on them.
    Sorry for the long postconf output.
    I did requeue all the messages with postsuper -r. I also put them all on hold (postsuper -h) which allowed for new messages to be delivered as usual. Deleting the queue was not an option. I am pretty sure now that it was a spam dictionary attack. But I am still concerned that this would effectively bring the server down.
    I looked into recipient restrictions but don't see any easy way to maintain an accurate list of my users. Is there a way to pull them from the LDAP directory? I guess I could do that with a perl script, shouldn't be too hard. Is there an easier way? Something built in?
    Anyway the server is fine now. As I said I put all the messages on hold then slowly released them back into the active queue. Once the server was able to get over its hang up it chewed through the remaining messages ok. This still brought my server down pretty much the entire day. Not acceptable in most countries.
    Any other ideas are welcome!
    Thanks,
    Josh
    shorter postconf output:
    alias_maps = hash:/etc/aliases,hash:/var/mailman/data/aliases
    always_bcc =
    bouncequeuelifetime = 4h
    command_directory = /usr/sbin
    config_directory = /etc/postfix
    content_filter = smtp-amavis:[127.0.0.1]:10024
    daemon_directory = /usr/libexec/postfix
    debugpeerlevel = 2
    defaultdestination_concurrencylimit = 6
    defaultprocesslimit = 20
    enableserveroptions = yes
    inet_interfaces = all
    initialdestinationconcurrency = 15
    localrecipientmaps =
    luser_relay = emailadmin
    mail_owner = postfix
    mailboxsizelimit = 0
    mailbox_transport = cyrus
    mailq_path = /usr/bin/mailq
    manpage_directory = /usr/share/man
    mapsrbldomains =
    maximalbackofftime = 2700s
    maximalqueuelifetime = 36h
    messagesizelimit = 16777216
    minimalbackofftime = 900s
    mydestination = $myhostname,localhost.$mydomain,myDomain.com
    mydomain_fallback = localhost
    myhostname = thestranger.com
    mynetworks = 127.0.0.1/32,10.0.0.0/24,10.0.8.0/24,10.0.1.0/24
    mynetworks_style = host
    newaliases_path = /usr/bin/newaliases
    ownerrequestspecial = no
    queue_directory = /private/var/spool/postfix
    queuerundelay = 900s
    readme_directory = /usr/share/doc/postfix
    recipient_delimiter = +
    relayhost =
    sample_directory = /usr/share/doc/postfix/examples
    sendmail_path = /usr/sbin/sendmail
    setgid_group = postdrop
    smtpconnecttimeout = 15s
    smtphelotimeout = 30s
    smtpdclientrestrictions = checkrecipientaccess hash:/etc/postfix/access, permitsaslauthenticated, permit_mynetworks, checksenderaccess hash:/etc/postfix/whiteList, rejectinvalidhostname, rejectnon_fqdnsender, rejectnon_fqdnrecipient, rejectrblclient dnsbl.njabl.org, rejectrblclient sbl-xbl.spamhaus.org, rejectrblclient bl.spamcop.net, rejectrblclient cbl.abuseat.org
    smtpdenforcetls = no
    smtpdpw_server_securityoptions = login,plain,cram-md5,gssapi
    smtpdrecipientrestrictions = checkrecipientaccess hash:/etc/postfix/access, permit_mynetworks, permitsaslauthenticated, rejectinvalidhostname, rejectnon_fqdnsender, rejectnon_fqdnrecipient, rejectunknown_senderdomain, rejectunauthdestination, checksenderaccess hash:/etc/postfix/whiteList
    smtpdsasl_authenable = yes
    smtpdtls_certfile = /etc/certificates//myDomain.com.crt
    smtpdtls_keyfile = /etc/certificates/myDomain.com.key
    smtpdtlsloglevel = 2
    smtpduse_pwserver = yes
    smtpdusetls = yes
    unknownlocal_recipient_rejectcode = 550
    virtualaliasmaps = hash:/etc/postfix/virtual,hash:/var/mailman/data/virtual-mailman
    virtualmailboxdomains = hash:/etc/postfix/virtual_domains
    virtual_transport = lmtp:unix:/Volumes/Mail/imap/socket/lmtp

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