Mail issues, cannot open or close

I cannot open my mailbox. I click on the stamp with the eagle on it, and on gray bar where things open up it says "mail", but i cannot write or read messages, and i cannot quit the application. No content is shown, no emails or anything. It is just my computer background. I tried to quit mail, but it will not let me do that. I cannot restart my computer, because mail is not closed. So if mail will not fully open, yet it is open enough to not be able to restart my computer without quitting, but there is no quit option and the commandQ button is not working ,how do i go about getting rid of this problem??

You seem to have some serious flaws on your harddisk.
Do you ever run maintenance software (e.g.
MacJanitor) or switch off your Mac every day? It's
doing some maintenance by itself in the middle of the
night if you leave it on.
This reply gets more & more detailed, just begin with
the first instructions and see of that helps. If not,
work down the list of suggestions or post back for
more instructions.
Run Disk Utility - Repair Permissions and if that
brings up a whole set of issues, try something more
serious like Disk Warrior.
MacJanitor (free)
DiskWarrior
(not free)
If you want more details on these problems, have a
look here for
Resolving Disk, Permission and Cache Corruption,
it gives you a comprehensive description of how to
deal with these problems. Plus some notes on side effects of cache cleaning
Useful Cache cleaning programs:
Cache Out X free
Tiger Cache Cleaner not free
OnyX
free
Thank you for your very prompt reply. I will follow your suggestions and post back. No, I do not use any other programme such as you have suggested. I usually put my computer to sleep overnight.
However, maybe I have discoverd a clue. When I opened e-mail Back Up just now, I got a message:
"Please finish editing and close the editing window before openiong a back up."
I fear I may have been working on an e-mail while thye Back Up was in progress. Coulod this have been a cause?
I also note that my back up programme dialogue box now tells me that there are no scheduled back ups for e-mail or for my home folder. I hesitate to instruct it to continue with back ups until I find out whatt the problem is.
Your help is greatly appreciated.

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