Mail Reset itself and delete signatures etc

Hi
I am using ML. The mail is playing with me... this is flustrating now...
It resets itself somehow...
My mails OK, everything works. But everytime I made signatures they will be dissapear soon.
Also the order of the accounts that I made in the left panel will be resets alphabetical order...
I don't know why these thing happens and even when they happenes. It's not after restart or something. Even if I don't swich off the macbook this is happening.
If someone has same problem and know the solution now please let me know.
Or let me know if it is a BUG or something and I/we need to wait for a upgrade from apple.
Too much problem is coming up newadays from Apple. I don't expect these from Apple.
Thank you so much.

Hi Mike,
Are your other APPs there, and your Dock the same?
Not certain, but this can fix myriad Mail problems...
Safe Boot from the HD, (holding Shift key down at bootup), it will try to repair your Disk Directory while the spinning radian is happening, so let it go, run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions, then move these folder & file to the Desktop.
Move this Folder to the Desktop...
/Users/YourUserName/Library/Caches/Mail/
Move this file to the Desktop...
/Users/YourUserName/Library/Mail/Envelope Index
Reboot.

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