Mail Server Error - 21055: auth: Error: od?

Hi,
Just upgraded to OSX 10.8 Mountain Lion, now my email services have gone AWOL.
The server logs are telling me  [DateTime domain.com] log[21055]:auth: Error: od (username, ip address): authentication failed for user=me, method=DIGEST-MD5
From a client (MS offlook) point of view I'm getting :
Your message did not reach some or all of the intended recipients.
Subject:    test
      Sent: 06/08/2012 19:09
The following recipient(s) cannot be reached:
      '[email protected]' on 06/08/2012 19:10
            451 4.3.5 <unknown[ip address]>: Client host rejected: Server configuration error
This used to work quite well with Lion and the Server Admin Tools.
Is there anything I can try?
Thanks in advance,
Jeff.

Thanks for getting back to me red shift, everything is now up and working again. 
I think it was somthing to do with some folder permissions and some mail settings.  The mail server GUI supplied with Mountain Lion is all but useless and didn't help in any way in tracking down or resolving the problem. So, I've taken the plunge and set up MailServ for Mountain lion, its a much better mail server GUI client, and seemed to correct some of my postfix settings.
I've tinkered a bit with command line mail stuff, but not quite at a level where I can fully administer it.
Are there any good command line resources out there?  This is somthing I need to improve on.
Cheers.

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    Connectivity Log on CAS01:
    2014-03-25T15:27:15.353Z,08D11605A575FAE1,SMTP,internalproxy,+,Undefined 00000000-0000-0000-0000-000000000000;QueueLength=<no priority counts>
    2014-03-25T15:27:15.353Z,08D11605A575FAE1,SMTP,internalproxy,>,"MBX02.myaddomain.com[10.10.10.12], MBX01.myaddomain.com[10.10.10.11]"
    2014-03-25T15:27:15.353Z,08D11605A575FAE1,SMTP,internalproxy,>,Established connection to 10.10.10.12
    2014-03-25T15:27:15.369Z,08D11605A575FAE1,SMTP,internalproxy,-,Messages: 0 Bytes: 0 (Attempting next target)
    2014-03-25T15:27:15.369Z,08D11605A575FAE2,SMTP,internalproxy,+,Undefined 00000000-0000-0000-0000-000000000000;QueueLength=<no priority counts>
    2014-03-25T15:27:15.369Z,08D11605A575FAE2,SMTP,internalproxy,>,Established connection to 10.10.10.11
    2014-03-25T15:27:15.369Z,08D11605A575FAE2,SMTP,internalproxy,-,Messages: 0 Bytes: 0 (Retry : EHLO Options do not match for proxy)
    2014-03-25T15:28:10.328Z,08D11605A575FAFA,SMTP,internalproxy,+,Undefined 00000000-0000-0000-0000-000000000000;QueueLength=<no priority counts>
    2014-03-25T15:28:21.669Z,08D11605A575FAFA,SMTP,internalproxy,>,"MBX01.myaddomain.com[10.10.10.11], MBX02.myaddomain.com[10.10.10.12]"
    2014-03-25T15:28:21.669Z,08D11605A575FAFA,SMTP,internalproxy,>,Established connection to 10.10.10.11
    2014-03-25T15:28:21.669Z,08D11605A575FAFA,SMTP,internalproxy,-,Messages: 0 Bytes: 0 (Attempting next target)
    2014-03-25T15:28:21.669Z,08D11605A575FAFF,SMTP,internalproxy,+,Undefined 00000000-0000-0000-0000-000000000000;QueueLength=<no priority counts>
    2014-03-25T15:28:21.669Z,08D11605A575FAFF,SMTP,internalproxy,>,Established connection to 10.10.10.12
    2014-03-25T15:28:21.669Z,08D11605A575FAFF,SMTP,internalproxy,-,Messages: 0 Bytes: 0 (Retry : EHLO Options do not match for proxy)
    SmtpSend Log on CAS01:
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,1,10.10.20.11:25495,10.10.10.12:25,+,,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,2,10.10.20.11:25495,10.10.10.12:25,<,220 ********************************************************************************************************************,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,3,10.10.20.11:25495,10.10.10.12:25,*,,Proxying inbound session with session id 08D11605A575FB5D
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,4,10.10.20.11:25495,10.10.10.12:25,>,EHLO CAS01.myaddomain.com,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,5,10.10.20.11:25495,10.10.10.12:25,<,250-MBX02.myaddomain.com Hello [10.10.20.11],
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,6,10.10.20.11:25495,10.10.10.12:25,<,250-SIZE,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,7,10.10.20.11:25495,10.10.10.12:25,<,250-PIPELINING,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,8,10.10.20.11:25495,10.10.10.12:25,<,250-DSN,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,9,10.10.20.11:25495,10.10.10.12:25,<,250-ENHANCEDSTATUSCODES,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,10,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXXA,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,11,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXXXXXXXXB,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,12,10.10.20.11:25495,10.10.10.12:25,<,250-AUTH NTLM,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,13,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXXXXXXXXXXXXC,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,14,10.10.20.11:25495,10.10.10.12:25,<,250-8BITMIME,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,15,10.10.20.11:25495,10.10.10.12:25,<,250-BINARYMIME,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,16,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXXD,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,17,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXXXE,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,18,10.10.20.11:25495,10.10.10.12:25,<,250-XXXXF,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,19,10.10.20.11:25495,10.10.10.12:25,<,250 XXXXXXXXXXXXXG,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,20,10.10.20.11:25495,10.10.10.12:25,*,,"EHLO options between current server and proxy target do not match : Chunking, Xrdst. Critical non
    matching options : Chunking, Xrdst. Failing over."
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,0,,10.10.10.11:25,*,,attempting to connect
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,21,10.10.20.11:25495,10.10.10.12:25,>,QUIT,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,1,10.10.20.11:25496,10.10.10.11:25,+,,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,22,10.10.20.11:25495,10.10.10.12:25,<,221 2.0.0 Service closing transmission channel,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB5E,23,10.10.20.11:25495,10.10.10.12:25,-,,Local
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,2,10.10.20.11:25496,10.10.10.11:25,<,220 ********************************************************************************************************************,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,3,10.10.20.11:25496,10.10.10.11:25,*,,Proxying inbound session with session id 08D11605A575FB5D
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,4,10.10.20.11:25496,10.10.10.11:25,>,EHLO CAS01.myaddomain.com,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,5,10.10.20.11:25496,10.10.10.11:25,<,250-MBX01.myaddomain.com Hello [10.10.20.11],
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,6,10.10.20.11:25496,10.10.10.11:25,<,250-SIZE,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,7,10.10.20.11:25496,10.10.10.11:25,<,250-PIPELINING,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,8,10.10.20.11:25496,10.10.10.11:25,<,250-DSN,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,9,10.10.20.11:25496,10.10.10.11:25,<,250-ENHANCEDSTATUSCODES,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,10,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXXA,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,11,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXXXXXXXXB,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,12,10.10.20.11:25496,10.10.10.11:25,<,250-AUTH NTLM,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,13,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXXXXXXXXXXXXC,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,14,10.10.20.11:25496,10.10.10.11:25,<,250-8BITMIME,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,15,10.10.20.11:25496,10.10.10.11:25,<,250-BINARYMIME,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,16,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXXD,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,17,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXXXE,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,18,10.10.20.11:25496,10.10.10.11:25,<,250-XXXXF,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,19,10.10.20.11:25496,10.10.10.11:25,<,250 XXXXXXXXXXXXXG,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,20,10.10.20.11:25496,10.10.10.11:25,*,,"EHLO options between current server and proxy target do not match : Chunking, Xrdst. Critical non
    matching options : Chunking, Xrdst. Failing over."
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,21,10.10.20.11:25496,10.10.10.11:25,>,QUIT,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,22,10.10.20.11:25496,10.10.10.11:25,<,221 2.0.0 Service closing transmission channel,
    2014-03-25T15:32:34.158Z,Inbound Proxy Internal Send Connector,08D11605A575FB67,23,10.10.20.11:25496,10.10.10.11:25,-,,Local
    Can anyone help? I'm at the end of my Googling!

    The answer has been found. In our case, we had to disable the Mailguard feature of the Cisco ASA between the CAS subnet and the MBX subnet. Essentially it was stripping AUTH commands from the SMTP handshake which meant the servers could not authenticate
    to each other and establish a secured connection.
    I guess for future reference, if you're getting a PRX4 error code you should look at any device that could be inspecting SMTP between your CAS and MBX servers.
    This Microsoft KB article has more information: http://support.microsoft.com/kb/320027

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