Mail stops responding when opening messages, replying, etc...

For the last few days I've been having an excessively annoying problem with Mail. Almost every time I select a message to view it hangs and goes unresponsive until I force quit it, normally I'd think it was because the message was large and it was just taking a long time to load it, but it happens even with completely text-based emails with only a few lines in them. It also happens when I try to reply to emails sometimes. The Mail app support folder is only 145MB, and I've tried restarting my computer and it still doesn't work.
Mail also doesn't seem to be hogging memory until it goes unresponsive.

Verify/repair the startup disk (not just permissions), as described here:
The Repair functions of Disk Utility: what's it all about?
Have you installed Safari 3 Beta ? If so, uninstall it and see whether that makes a difference.
Do you have any Mail plug-ins or system utilities that could interfere with Mail? In the Finder, go to each of the following folders (if they exist). What do you see there?
/Library/InputManagers/
/Library/Mail/Bundles/
~/Library/InputManagers/
~/Library/Mail/Bundles/
Note: For those not familiarized with the ~/ notation, it refers to the user’s home folder. You can easily locate any of the folders referred to in this post by copying the folder path here, doing Go > Go to Folder in the Finder, and pasting the folder path there.

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