Mail unexpectedly quits when I try to open the Mail Application 4.5 and system is 10.6.8

Mail unexpectedly quits when I try to open the Mail Application 4.5.
Any ideas how to resolve this?
I have tried the suggestions already given on Lists, and nothing has yet worked...

10.6.8 is not Mountain Lion.
How big is your hard drive, and how full is it?
Did you happen to download any system cache cleaners?  Those can damage its ability to function.
Have you tried repairing permissions?
Is your data backed up?
Is Spotlight indexed?
Is the Mail trying to load an IMAP, POP or Exchange account?
I've requested this thread be moved, no need to repost.

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