Mail will not open hot links

Mail has suddenly stopped opening hot links
when lonk is clicked i get a mail error message
and "no associated application could be found"
I have not changed any settings

Safe Boot from the HD, (holding Shift key down at bootup), run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions...
Reset Launch Services...
http://www.thexlab.com/faqs/resetlaunchservices.html#Anchor-Reset-47857
Reboot.
PS. Safe boot may stay on the gray radian for a long time, let it go, it's trying to repair the Hard Drive.

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