Mail won't open - please help me if you can I'm feeling down .... and I do

Hello everyone - never used this before so I don't know quite where it will arrive - BUT, HELP - my Mail program just will not load - I press the icon in the sidebar and it just hops and that's it! I hold the menue open and click 'open' and the same, just one frustrating hop. I did notice yesterday something odd - some mail in had one subject, and then when I opened it, it was the content from another sender. Have updated to 10.4.8 in the last week. My summary comment as simply 'aaaaaaaaarrrrrrggggghhhhhhh!!!!!' - and I have so much in various mailboxes which I need to access on a regular basis.
Any ideas for a new boy who is somewhat challenged tech-wise????
Thanks
DavidI

Hello DavidI.
Verify/repair the startup disk (not just permissions), as described here:
The Repair functions of Disk Utility: what's it all about?
After having fixed all filesystem issues, if any, proceed as follows to try to identify the problem:
1. Open /Applications/Utilities/Console.
2. From the File menu, choose either Open Console Log, or Open System Log, or both, so that the Console application displays the contents of both system.log and console.log.
3. In the Finder, go to /Applications/, and try to open Mail by double-clicking on it. Look at the bottom of the Console windows for messages that might be written there as a result. They may provide some clues as to what the problem is.
In the meanwhile, take a look at the following article, in case this is a font issue:
Font Management in Mac OS X Tiger and Panther
You may also want to read the following article:
Multiple applications quit unexpectedly or fail to launch

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I am running 10.5.1 Leopard on a brand new MPro and for some unknown reason Mail will not open anymore. The menu will come up but the rest of the app won't load. Then it won't quit and I have to force quit to close it.
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