Mail won't open reply window & can't type since upgrading to 10.4.6

like the subject says, ever since I updated my OS to 10.4.6, Mail won't open a reply window when trying to reply to a received e-mail. Also, when trying to type a new email message, can only type until the space bar is hit, then get the error sound and no more characters can be typed. Tried repairing/verifying disk permissions several times and checked disk as well, but still won't work properly. Mozilla mail works without any problem, so it must be a Mac Mail thing...
thanks for any ideas...maybe this stuff needs to be tested better before OS updates are put out...will this and all of us be abandoned to Intel MacOS in the near future?

Most people having this issue have successfully solved it cleaning up the LaunchServices cache. The following article describes how to manually reset LaunchServices. The notes at the bottom of the article also provide information about the side effects of deleting each of the files involved.
Resetting Launch Services
The following article also describes the side effects of cache cleaning:
Side effects of System cache cleaning
The following article provides links to some utilities that can be used for troubleshooting and cache cleaning:
Resolving Disk, Permission, and Cache Corruption
It seems that the most appropriate utility for solving this particular problem is Tiger Cache Cleaner.
In addition to the utilities mentioned above, you may also consider OnyX, if for no other reason, because it's free. If you want to try OnyX, after installing it, do this (be sure to read the articles about the side effects of cache cleaning first):
1. Quit all applications.
2. Launch OnyX and enter your administrator password.
3. Click Maintenance. In the Reset section, check LaunchServices database.
4. You may uncheck any other pre-checked options if you've already done them using other utilities.
5. Click the Execute button.
If that doesn't solve the problem, you may try again checking the Links between documents and applications option in step 3 instead.
Please let me know whether you were able to solve the problem, what worked for you and what didn't.

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Hello ward886,
Thank you for the question. It sounds like Mail is unresponsive, and you are unable to access it or restart your system. In a situation like this, I recommend force quitting Mail and restarting your computer.
Use one of the following methods to force Mail to quit:
Using the Force Quit feature of OS X makes an application close, even when it is not responsive.
Important: Normally you should not need to force quit an app to close it. When an app is forced to quit, any unsaved changes to open documents are not saved, so try these methods to normally close the app first:
Choose Quit from the app menu. For example, in Safari, choose Safari > Quit Safari.
Choose Quit by right-clicking or control-clicking on an app's icon in the Dock.
If your app does not close using the steps above, use any of these steps to force the app to quit:
Switch to another app, such as the Finder, then choose Force Quit from the Apple menu. Select the unresponsive app in the Force Quit window, and click Force Quit.
Press Command-Option-Esc, then select the unresponsive app from the Force Quit window that appears, and click Force Quit.
Hold down the Control and Option keys on your keyboard, and click the icon of the unresponsive app in the Dock. Select Force Quit from the menu that appears.
Open Activity Monitor from the Utilities folder or the Spotlight menu. Select the unresponsive app in the Activity monitor window. Choose Quit Process from the View menu, or click the Force Quit button in the toolbar of the Activity Monitor window.
If you cannot switch from the unresponsive app, press Command-Option-Shift-Esc for three seconds to force it to quit. This key combination tells OS X to force quit the frontmost app.
Find the full article here:
OS X: How to quit an unresponsive application using Force Quit
http://support.apple.com/kb/ht3411
Thank you for using Apple Support Communities.
Best,
Sheila M.

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Same here.
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Mac OS & System Software
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My mail won't open and keeps on "not responding"

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Do a backup.
Go to Finder and select your user/home folder. With that Finder window as the front window, either select Finder/View/Show View options or go command - J. When the View options opens, check ’Show Library Folder’. That should make your user library folder visible in your user/home folder. Go to Library/Containers/com.apple.mail. Move the folder com.apple.mail to your desktop. You must move the entire folder, not just the contents.
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OS X: How to quit an unresponsive application using Force Quit
If Mail still doesn't open, see below.
Launch the Console application in any of the following ways:
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Please don't indiscriminately dump thousands of lines from the log into this discussion.
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Hi there,
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OT

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Hi,
I am going to reply to my own question.
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Too simple I guess!!!!
Regards.
Alain.

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7:29 pm Sunday; October 27, 2013
 iMac 2.5Ghz 5i 2011 (Mountain Lion 10.8.4)
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Mail won't open reply window & can't type since upgrading to 10.4.6

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