Mailbox DB copy alternating between Resynchronizing and Disconnected and Resynchronizing

We have run into this issue before.  but I wanted to see if anyone can help me pinpoint a cause and potentially a fix.
My Environment:
exch1: 2008r2, version 10 sp3, rollup8-v2; ver #:(14.3 build 123.4)
this box has a LAN: 192.168.1.100 and a backupnet: 182.168.100.100
exch2: 2008r2, version 10 sp3, rollup8-v2; ver #:(14.3 build 123.4)
this box has a LAN: 192.168.1.101 and a backupnet: 182.168.100.101
drexch: 2008r2, version 10 sp3, rollup8-v2; ver #:(14.3 build 123.4)
this box has a LAN: 192.168.10.100 NOTE: this box is in another facility connected over a WAN and a VPN between the two sites)
As the title suggests, I have a mailbox db copy that always alternates from Resynchronizing to Disconnected and Resynchronizing
Currently, my exch2 box hosts the DB and the copies are being sent to drexch and exch1. 
As for dag networks, I have 2 networks defined.
Network1 uses all the LAN ip address
It is defined as such
Subnets
  192.168.1.0/24
  192.168.10.0/24
Network Interfaces
  192.168.10.100
  192.168.1.100
  192.168.1.101
Network 2 uses all the backupnet ip address
It is defined as such:
Subnets
  182.168.100.0/24
Network Interfaces
  182.168.100.100
  182.168.100.101
The only thing that will temporarily resolve this issue is if I disable replication over the backupnet DAG network.  After that, the DB copy will return to Healthy and the copy queue length returns to 0.
We had this all working properly, replication was enabled on both DAG networks, and it all worked until this last Thursday, I installed windows updates and it updated all 3 exchange boxes to sp3 rollup8-v2
I updated the exchange boxes in this order
exch2 as it was the passive.  After a reboot I performed a DB copy move to exch2, then after all were healthy, I updated exch1 and rebooted.  After that I installed updates on drexch and rebooted.  What was interesting was, drexch was disconnected
and had a copy queue of like 100000.  I right clicked and enabled the sync.  it took a while but eventually went down to 0.  After that, this is when the issues seemed to have started.  I am not saying they are related, but they might be.
Let me know if anyone has any suggestions.
Thanks,
Ian
Ian

Hi,
It's recommended to have two NICs for each DAG member, one for MAPI and the other for Replication. Generally, we enable replication traffic on Replication network, and disable on MAPI network.
Please check the network setting on server drexch in DR site, make sure you configure network settings properly. And make sure MAPI network is at the top of the connection order.
Have you tried to reseed database on server drexch to check result?
If you don't, you can reseed database on server drexch to check if this issue persists.
Best regards,
Belinda Ma
TechNet Community Support

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